Symptoms:  Protruding eyes, seemingly ready to "pop" out of socket.  As some puffers already have this characteristic, be certain that its eyes are experiencing additional swelling.  Some cloudiness of the eye may occur as well.

Treatment:  Broad spectrum anti-biotics geared towards gram-negative bacteria.  (tetracycline, "Maracyn-Two" and the like)

Background:  Pop Eye disease can be caused by many gram-negative bacteria.  During such an infection, pressure may build in or behind the eyes, making them protrude.  The very term "pop eye disease" is misleading, as it can be used to describe the symptoms of several other ailments.  It is because of this that treatment involves the use of broad-spectrum anti-biotics.